Are there exceptions to Basic Strategy in blackjack for certain hand compositions?
Answer: This is true. And it's possible to wring a tiny drop of blood out of the proverbial stone by using the exceptions. I'm aware of only three cases – there may be others – and the effect is quite small. Most players would be better off getting basic strategy down pat than worrying about these anomalies.
Here's what I mean. Assume a six-deck game, doubling allowed after splitting. Most experienced players would split pairs of sixes against dealer upcards of two through six, and stand on all other hard totals of 12. Under basic strategy, the splitting is correct but the player should hit versus two or three, and stand versus four through six. The exception occurs when the dealer has four-up. In this instance, it's correct to stand with 7-5, 8-4, and 9-3 but hit 10-2. How much better? Averaged over huge numbers of games, hitting is worth $7 per $1,000 wagered in this particular situation -- or $1 for every $20,000 bet in all.
The other cases I know involve dealer 10-up. a) Hit any 2-card 16 but stand on a 3-card 16. b) If late surrender is offered, use this option with 10-5 or 9-6 but hit 8-7. Statistically, in a six-deck game, the hit is worth $0.20 per $1,000 wagered under these circumstances -- or $1 for every $2.7 million bet in all.